H2N2V1, Main, Exploration, bibRecord, 002B03

Preparation and characterization of live recombinant influenza vaccine.

Identifieur interne : 002B03 ( Main/Exploration ); précédent : 002B02; suivant : 002B04

Preparation and characterization of live recombinant influenza vaccine.

Auteurs : V M Stealey ; D. Mccahon ; D S Freestone

Source :

Developments in biological standardization [ 0301-5149 ] ; 1976.

RBID : pubmed:955267

Descripteurs français

KwdFr :
- Administration par voie nasale, Anticorps antiviraux (analyse), Humains, Nez (microbiologie), Orthomyxoviridae (immunologie), Recombinaison génétique, Sang (microbiologie), Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (administration et posologie), Virus de la grippe A (immunologie), Virus de la grippe A (isolement et purification).
MESH :
- administration et posologie : Vaccins antigrippaux.
- analyse : Anticorps antiviraux.
- immunologie : Orthomyxoviridae, Virus de la grippe A.
- isolement et purification : Virus de la grippe A.
- microbiologie : Nez, Sang.
- Administration par voie nasale, Humains, Recombinaison génétique, Tests d'inhibition de l'hémagglutination.

English descriptors

KwdEn :
- Administration, Intranasal, Antibodies, Viral (analysis), Blood (microbiology), Hemagglutination Inhibition Tests, Humans, Influenza A virus (immunology), Influenza A virus (isolation & purification), Influenza Vaccines (administration & dosage), Nose (microbiology), Orthomyxoviridae (immunology), Recombination, Genetic.
MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- immunology : Influenza A virus, Orthomyxoviridae.
- isolation & purification : Influenza A virus.
- microbiology : Blood, Nose.
- Administration, Intranasal, Hemagglutination Inhibition Tests, Humans, Recombination, Genetic.

Abstract

Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.

PubMed: 955267

Affiliations:

Le document en format XML

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<author><name sortKey="Stealey, V M" sort="Stealey, V M" uniqKey="Stealey V" first="V M" last="Stealey">V M Stealey</name>
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<author><name sortKey="Mccahon, D" sort="Mccahon, D" uniqKey="Mccahon D" first="D" last="Mccahon">D. Mccahon</name>
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<author><name sortKey="Freestone, D S" sort="Freestone, D S" uniqKey="Freestone D" first="D S" last="Freestone">D S Freestone</name>
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<author><name sortKey="Mccahon, D" sort="Mccahon, D" uniqKey="Mccahon D" first="D" last="Mccahon">D. Mccahon</name>
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<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (isolation & purification)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Nose (microbiology)</term>
<term>Orthomyxoviridae (immunology)</term>
<term>Recombination, Genetic</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term>
<term>Anticorps antiviraux (analyse)</term>
<term>Humains</term>
<term>Nez (microbiologie)</term>
<term>Orthomyxoviridae (immunologie)</term>
<term>Recombinaison génétique</term>
<term>Sang (microbiologie)</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus de la grippe A (isolement et purification)</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
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<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Orthomyxoviridae</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
<term>Orthomyxoviridae</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la grippe A</term>
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<term>Sang</term>
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<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Blood</term>
<term>Nose</term>
</keywords>
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<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Recombination, Genetic</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term>
<term>Humains</term>
<term>Recombinaison génétique</term>
<term>Tests d'inhibition de l'hémagglutination</term>
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<front><div type="abstract" xml:lang="en">Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.</div>
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<name sortKey="Mccahon, D" sort="Mccahon, D" uniqKey="Mccahon D" first="D" last="Mccahon">D. Mccahon</name>
<name sortKey="Stealey, V M" sort="Stealey, V M" uniqKey="Stealey V" first="V M" last="Stealey">V M Stealey</name>
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Serveur d'exploration H2N2

Preparation and characterization of live recombinant influenza vaccine.

Preparation and characterization of live recombinant influenza vaccine.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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